Substrate recognition diversity and transport dynamics of ABCC1

Abstract ABCC1 is an ATP-binding cassette (ABC) transporter that exports diverse endogenous and exogenous substrates, conferring resistance to many anticancer drugs and mediating various physiological functions. Here, we present ten cryo-EM structures of ABCC1 in different functional states, providi...

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Autors principals:	Panpan Sun, Kexin Liu, Linnan Zhang, Qixiang Zhang, Yina Gao, Zhaolong Li, Yalan Zhu, Songqing Liu, Liguo Zhang, Ang Gao, Pu Gao
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-11-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-025-65501-9
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