Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy

Abstract Background KRAS mutations are fraught with the progression of colorectal cancer and resistance to chemotherapy. There are pathways such as extracellular regulated protein kinase 1/2 (ERK1/2) and Akt downstream and farnesylation and geranylgeranylation upstream that are activated upon mutate...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Kana Kishimoto, Honoka Takefuji, Yuzuki Taniwaki, Misa Ueda, Tadafumi Hoshida, Kazufumi Tanabe, Shozo Nishida
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2023-04-01
Sarja:	Cancer Cell International
Aiheet:	Colorectal cancer Statin Oxaliplatin KRAS Neuropathy
Linkit:	https://doi.org/10.1186/s12935-023-02884-z
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!