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Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy

Abstract Background KRAS mutations are fraught with the progression of colorectal cancer and resistance to chemotherapy. There are pathways such as extracellular regulated protein kinase 1/2 (ERK1/2) and Akt downstream and farnesylation and geranylgeranylation upstream that are activated upon mutate...

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Wedi'i Gadw mewn:
Prif Awduron: Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Kana Kishimoto, Honoka Takefuji, Yuzuki Taniwaki, Misa Ueda, Tadafumi Hoshida, Kazufumi Tanabe, Shozo Nishida
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2023-04-01
Cyfres:Cancer Cell International
Pynciau:
Colorectal cancer
Statin
Oxaliplatin
KRAS
Neuropathy
Mynediad Ar-lein:https://doi.org/10.1186/s12935-023-02884-z
Tagiau: Ychwanegu Tag
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