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Paracrine Met signaling triggers epithelial–mesenchymal transition in mammary luminal progenitors, affecting their fate

HGF/Met signaling has recently been associated with basal-type breast cancers, which are thought to originate from progenitor cells residing in the luminal compartment of the mammary epithelium. We found that ICAM-1 efficiently marks mammary luminal progenitors comprising hormone receptor-positive a...

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Principais autores: Amandine Di-Cicco, Valérie Petit, Aurélie Chiche, Laura Bresson, Mathilde Romagnoli, Véronique Orian-Rousseau, Maria dM Vivanco, Daniel Medina, Marisa M Faraldo, Marina A Glukhova, Marie-Ange Deugnier
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2015-07-01
Serier:eLife
Fag:
mammary gland
stem cell
Met signaling
epithelial–mesenchymal transition
ICAM-1
Online adgang:https://elifesciences.org/articles/06104
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