Alpha-6 integrin deletion delays the formation of Brca1/p53-deficient basal-like breast tumors by restricting luminal progenitor cell expansion

Abstract Background The aberrant amplification of mammary luminal progenitors is at the origin of basal-like breast cancers associated with BRCA1 mutations. Integrins mediate cell–matrix adhesion and transmit mechanical and chemical signals that drive epithelial stem cell functions and regulate tumo...

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Principais autores:	Marisa M. Faraldo, Mathilde Romagnoli, Loane Wallon, Pierre Dubus, Marie-Ange Deugnier, Silvia Fre
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-06-01
Colecção:	Breast Cancer Research
Assuntos:	Brca1/p53-deficient tumors Luminal progenitors Laminin-binding integrins
Acesso em linha:	https://doi.org/10.1186/s13058-024-01851-4
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