Non-canonical STING activation by calcium influx paired to endoplasmic reticulum stress
Abstract STING plays a pivotal role in initiating antiviral and proinflammatory responses in vertebrates. cGAS detection of cytosolic dsDNA, leads to the synthesis of 2′3’-cGAMP that subsequently binds to STING, mediating its canonical activation. Activation of STING triggers a signaling cascade tha...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BMC
2026-04-01
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| Col·lecció: | Cell Communication and Signaling |
| Accés en línia: | https://doi.org/10.1186/s12964-026-02819-x |
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