Divergent macrophage responses to Influenza A virus and Streptococcus pneumoniae: co-infection drives bacterial dominance whereas superinfection favors viral priming

IntroductionRespiratory coinfections involving Influenza viruses, including Influenza A viruses (IAV) and bacteria, significantly worsen disease severity and remain a major public health concern, particularly during seasonal and pandemic flu outbreaks. Among bacterial pathogens, Streptococcus pneumo...

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Principais autores:	Javier Arranz-Herrero, Jana Baranda, Sergio Rius-Rocabert, Mikel Moreno-Vadillo, Ivan Gonzalez-Ruiz, Alberto Miranda-Bedate, Elena Pinelli, Ines Inchausti-Moya, Sara Izpura-Luis, Vicent Tur-Planells, Paloma Reche, Paloma Fernandez, Yolanda Revilla, Gustavo Del Real, Adolfo García-Sastre, César B Gutiérrez-Martín, Jordi Ochando, Estanislao Nistal-Villan
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2026-03-01
Serija:	Frontiers in Immunology
Teme:	coinfection in vitro influenza Streptococcus superinfection transcriptomics
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1729086/full
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