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Environmental Risk Factors and Parkinson's Disease: Selective Degeneration of Nigral Dopaminergic Neurons Caused by the Herbicide Paraquat

Environmental toxicants and, in particular, pesticides have been implicated as risk factors in Parkinson's disease (PD). The purpose of this study was to determine if selective nigrostriatal degeneration could be reproduced by systemic exposure of mice to the widely used herbicide paraquat. Repeated...

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Principais autores: Alison L. McCormack, Mona Thiruchelvam, Amy B. Manning-Bog, Christine Thiffault, J.William Langston, Deborah A. Cory-Slechta, Donato A. Di Monte
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2002-07-01
coleção:Neurobiology of Disease
Assuntos:
dopamine
pesticide
substantia nigra
striatum
GABA
stereology
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996102905073
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