Cypripedin Induces Apoptosis and Synergizes with Bortezomib via ER Stress Mediated Ubiquitination of GRP78 in T-Cell Acute Lymphoblastic Leukemia

Background: T-cell acute lymphoblastic leukemia (T-ALL) remains a challenging malignancy with limited targeted therapies. Natural phenanthrene derivatives represent a promising source of antileukemic agents. Objective: We screened a library of natural phenanthrene-type compounds to identify cytotoxi...

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Bibliografski detalji

Glavni autori:	Zin Zin Ei, Bodee Nutho, Boonchoo Sritularak, Pithi Chanvorachote, Preedakorn Chunhacha
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2026-05-01
Serija:	Molecules
Teme:	cypripedin Jurkat cells T-ALL apoptosis bortezomib endoplasmic reticulum stress
Online pristup:	https://www.mdpi.com/1420-3049/31/11/1823
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