Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction

Abstract Background The leading cause of cancer-related mortality worldwide is lung cancer, and its clinical outcome and prognosis are still unsatisfactory. The understanding of potential molecular targets is necessary for clinical implications in precision diagnostic and/or therapeutic purposes. Hi...

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Hlavní autoři:	Onsurang Wattanathamsan, Naphat Chantaravisoot, Piriya Wongkongkathep, Sakkarin Kungsukool, Paninee Chetprayoon, Pithi Chanvorachote, Chanida Vinayanuwattikun, Varisa Pongrakhananon
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-01-01
Edice:	Journal of Biomedical Science
Témata:	Extracellular signal-regulated kinase (ERK) Glucose-regulated protein 78 (GRP78) Histone deacetylase 6 (HDAC6) Lung cancer Tubulin acetylation
On-line přístup:	https://doi.org/10.1186/s12929-023-00898-3
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