Glucose-1,6-bisphosphate: A new gatekeeper of cerebral mitochondrial pyruvate uptake

Objective: Glucose-1,6-bisphosphate (G-1,6-BP), a byproduct of glycolysis that is synthesized by phosphoglucomutase 2 like 1 (PGM2L1), is particularly abundant in neurons. G-1,6-BP is sensitive to the glycolytic flux, due to its dependence on 1,3-bisphosphoglycerate as phosphate donor, and the energ...

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Hlavní autoři:	Motahareh Solina Safari, Priska Woerl, Carolin Garmsiri, Dido Weber, Marcel Kwiatkowski, Madlen Hotze, Louisa Kuenkel, Luisa Lang, Matthias Erlacher, Ellen Gelpi, Johannes A. Hainfellner, Gottfried Baier, Gabriele Baier-Bitterlich, Stephanie zur Nedden
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-10-01
Edice:	Molecular Metabolism
Témata:	Energy metabolism Phosphoglucomutase 2 like 1 Glucose-1,6-bisphosphate Mitochondrial pyruvate carrier Ischemia Protein kinase N1
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2212877824001492
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