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The Volume-Regulated Anion Channel LRRC8 is Involved in the Initiation of Epidermal Differentiation and is Deregulated in Psoriasis

Recent studies have shown that LRRC8A, the essential subunit of the volume-regulated anion channel LRRC8, which is responsible for mediating cell volume regulation during hypotonic stress, is predominantly localized in the basal layer of the epidermis. This prompted us to investigate whether LRRC8A...

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Principais autores: Magdalena Jahn, Victoria Lang, Oliver Rauh, Torsten Fauth, Claudia Buerger
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-05-01
Serier:JID Innovations
Fag:
Epidermal differentiation
Keratinocytes
Ion channel
LRRC8
SWELL1
Online adgang:http://www.sciencedirect.com/science/article/pii/S266702672500013X
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