FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer

Abstract Purpose The claudin 18.2 (CLDN18.2) antigen is frequently expressed in malignant tumors, including pancreatic ductal adenocarcinoma (PDAC). Although CLDN18.2-targeted CAR-T cells demonstrated some therapeutic efficacy in PDAC patients, further improvement is needed. One of the major obstacl...

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Detalhes bibliográficos

Principais autores:	Yifan Liu, Yansha Sun, Peng Wang, Songling Li, Yiwei Dong, Min Zhou, Bizhi Shi, Hua Jiang, Ruixin Sun, Zonghai Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-04-01
coleção:	Journal of Translational Medicine
Acesso em linha:	https://doi.org/10.1186/s12967-023-04080-z
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