Pyruvate kinase M1 regulates butyrate metabolism in cancerous colonocytes

Abstract Colorectal cancer (CRC) cells shift metabolism toward aerobic glycolysis and away from using oxidative substrates such as butyrate. Pyruvate kinase M1/2 (PKM) is an enzyme that catalyzes the last step in glycolysis, which converts phosphoenolpyruvate to pyruvate. M1 and M2 are alternatively...

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Autors principals:	Bohye Park, Ji Yeon Kim, Olivia F. Riffey, Presley Dowker-Key, Antje Bruckbauer, James McLoughlin, Ahmed Bettaieb, Dallas R. Donohoe
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2022-05-01
Col·lecció:	Scientific Reports
Accés en línia:	https://doi.org/10.1038/s41598-022-12827-9
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