Quantifying immune-based counterselection of somatic mutations.
Somatic mutations in protein-coding regions can generate 'neoantigens' causing developing cancers to be eliminated by the immune system. Quantitative estimates of the strength of this counterselection phenomenon have been lacking. We quantified the extent to which somatic mutations are depleted in p...
שמור ב:
| Principais autores: | , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Public Library of Science (PLoS)
2019-07-01
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| סדרה: | PLoS Genetics |
| גישה מקוונת: | https://doi.org/10.1371/journal.pgen.1008227 |
| תגים: |
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