Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: The role, regulation and restoration of LRP1

Amyloid beta (Aβ) homeostasis in the brain is governed by its production and clearance mechanisms. An imbalance in this homeostasis results in pathological accumulations of cerebral Aβ, a characteristic of Alzheimer’s disease (AD). While Aβ may be cleared by several physiological mechanisms, a major...

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Principais autores:	Anita eRamanathan, Amy R. Nelson, Abhay P. Sagare, Berislav V. Zlokovic
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2015-07-01
Colecção:	Frontiers in Aging Neuroscience
Assuntos:	Blood-Brain Barrier Alzheimer’s disease (AD) PICALM Amyloid β clearance lipoprotein receptor-related protein 1 (LRP1)
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00136/full
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