Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: The role, regulation and restoration of LRP1

Amyloid beta (Aβ) homeostasis in the brain is governed by its production and clearance mechanisms. An imbalance in this homeostasis results in pathological accumulations of cerebral Aβ, a characteristic of Alzheimer’s disease (AD). While Aβ may be cleared by several physiological mechanisms, a major...

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Үндсэн зохиолчид:	Anita eRamanathan, Amy R. Nelson, Abhay P. Sagare, Berislav V. Zlokovic
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2015-07-01
Цуврал:	Frontiers in Aging Neuroscience
Нөхцлүүд:	Blood-Brain Barrier Alzheimer’s disease (AD) PICALM Amyloid β clearance lipoprotein receptor-related protein 1 (LRP1)
Онлайн хандалт:	http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00136/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!