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Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours

Abstract Background Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric patients highlighting the need to establish robust biomarkers for patient selection. While the tumour microenvironment...

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Kaydedildi:
Asıl Yazarlar: Arash Nabbi, Pengbo Beck, Alberto Delaidelli, Derek A. Oldridge, Sumedha Sudhaman, Kelsey Zhu, S. Y. Cindy Yang, David T. Mulder, Jeffrey P. Bruce, Joseph N. Paulson, Pichai Raman, Yuankun Zhu, Adam C. Resnick, Poul H. Sorensen, Martin Sill, Sebastian Brabetz, Sander Lambo, David Malkin, Pascal D. Johann, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Natalie Jäger, Trevor J. Pugh
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2023-09-01
Seri Bilgileri:Genome Medicine
Konular:
Paediatric neuro-oncology
Immunogenomics
CNS tumours
Tumour microenvironment
Neuroblastoma
Online Erişim:https://doi.org/10.1186/s13073-023-01219-x
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