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Pleiotropic roles of the MATE transporter CD20030 in Clostridioides difficile: linking multidrug resistance to oxidative stress defense and virulence regulation

BackgroundThe multidrug-resistant pathogen Clostridioides difficile (C. difficile) presents a persistent clinical threat. While Multidrug and Toxic Compound Extrusion (MATE) transporters are recognized as xenobiotic efflux pumps, their pleiotropic roles in pathogen physiology, particularly in stress...

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Principais autores: Jie Deng, Fa Hui Chen, Wen Jing Wu, Ting Yu Huang, Gu Zhen Cui, Wei Hong
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-07-01
Serier:Frontiers in Microbiology
Fag:
Clostridioides difficile
CRISPR-Cas9
MATE efflux pump
oxidative stress
virulence regulation
Online adgang:https://www.frontiersin.org/articles/10.3389/fmicb.2026.1865850/full
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