Pleiotropic roles of the MATE transporter CD20030 in Clostridioides difficile: linking multidrug resistance to oxidative stress defense and virulence regulation

BackgroundThe multidrug-resistant pathogen Clostridioides difficile (C. difficile) presents a persistent clinical threat. While Multidrug and Toxic Compound Extrusion (MATE) transporters are recognized as xenobiotic efflux pumps, their pleiotropic roles in pathogen physiology, particularly in stress...

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Hlavní autoři:	Jie Deng, Fa Hui Chen, Wen Jing Wu, Ting Yu Huang, Gu Zhen Cui, Wei Hong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-07-01
Edice:	Frontiers in Microbiology
Témata:	Clostridioides difficile CRISPR-Cas9 MATE efflux pump oxidative stress virulence regulation
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fmicb.2026.1865850/full
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