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High serum ferritin is associated with genetic instability in myelodysplastic neoplasms

Abstract Purpose Serum ferritin is an independent prognostic marker in myelodysplastic neoplasms (MDS) and serves as a surrogate parameter for iron overload. Oxidative stress derived from iron overload may induce genomic damage, thereby promoting genetic instability and disease progression in MDS. W...

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Principais autores: Christina Ganster, Hannes Treiber, Gina Westhofen, Fabian Beier, Tienush Rassaf, Haifa Kathrin Al-Ali, Reingard Stuhlmann, Bertram Glass, Ulrike Bacher, Katayoon Shirneshan, Tim H. Brümmendorf, Ulrich Germing, Norbert Gattermann, Detlef Haase
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2026-04-01
Colecção:Journal of Cancer Research and Clinical Oncology
Assuntos:
Myelodysplastic neoplasm
Iron overload
Genetic instability
γH2AX
Telomere
Serum ferritin
Acesso em linha:https://doi.org/10.1007/s00432-026-06457-1
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