AI-driven multimodal algorithm predicts immunotherapy and targeted therapy outcomes in clear cell renal cell carcinoma

Summary: Treatment for metastatic clear cell renal cell carcinoma (ccRCC) has dramatically advanced with tyrosine kinase inhibitor (TKI) and immune checkpoint inhibitor (ICI) administration. However, most patients eventually succumb to their disease, and toxicities associated with individual treatme...

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Autors principals:	Danil Stupichev, Natalia Miheecheva, Ekaterina Postovalova, Yang Lyu, Akshaya Ramachandran, Ilya Galkin, Gleb Khegai, Kristina Perevoshchikova, Anna Love, Sofia Menshikova, Artem Tarasov, Viktor Svekolkin, Maria Bruttan, Arina Varlamova, Kirill Kriukov, Ravshan Ataullakhanov, Nathan Fowler, Emily Cheng, Alexander Bagaev, James J. Hsieh
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-08-01
Col·lecció:	Cell Reports Medicine
Matèries:	clear cell renal cell carcinoma predictive biomarkers tyrosine kinase inhibitors immune checkpoint inhibitors single-cell proteogenomics tumor heterogeneity
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2666379125003726
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