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A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis

Abstract Renal medullary carcinoma is a rare undifferentiated tumor of the kidney associated with sickle cell trait and characterized by INI1 (SMARCB1) loss. Although metastasis to lungs, lymph nodes, and bone is commonly reported, distant spread to the central nervous system almost never occurs. He...

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Autori principali: Maria A. Gubbiotti, Ian E. McCutcheon, Priya Rao, Giannicola Genovese, Linghua Wang, Artem Tarasov, Vladislav Putintsev, Amber Berlinski, Danil Stupichev, Kirill Kriukov, Suren Davitavyan, Basim Salem, Alexander Sarachakov, Dmitry Lebedev, Michael Hensley, Alexander Bagaev, Francesca Paradiso, Vladimir Kushnarev, Gleb Khegai, Nizar M. Tannir, Pavlos Msaouel
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-01-01
Serie:Acta Neuropathologica Communications
Soggetti:
Renal medullary carcinoma
INI1
SMARCB1
Glial transdifferentiation
Tazemetostat
EZH2
Accesso online:https://doi.org/10.1186/s40478-025-01929-w
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