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PPS, a large multidomain protein, functions with sex-lethal to regulate alternative splicing in Drosophila.

Alternative splicing controls the expression of many genes, including the Drosophila sex determination gene Sex-lethal (Sxl). Sxl expression is controlled via a negative regulatory mechanism where inclusion of the translation-terminating male exon is blocked in females. Previous studies have shown t...

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Autors principals: Matthew L Johnson, Alexis A Nagengast, Helen K Salz
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2010-03-01
Col·lecció:PLoS Genetics
Accés en línia:http://europepmc.org/articles/PMC2832672?pdf=render
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