Pharmacometrics modeling and simulation to assist phenobarbital dose optimization in dogs

IntroductionPhenobarbital (PB) remains the first-line treatment for canine epilepsy due to its efficacy, affordability, and favorable pharmacokinetics. However, its narrow therapeutic index and substantial interindividual variability necessitate therapeutic drug monitoring (TDM) and individualized d...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Silvana Alvariza, Manuel Ibarra, Natalia Guevara, Cecilia Maldonado, Marta Vázquez, Gimena Feijoó, Gonzalo Suárez
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2025-09-01
Σειρά:	Frontiers in Veterinary Science
Θέματα:	phenobarbital population pharmacokinetics therapeutic drug monitoring model-informed precision dosing canine epilepsy
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fvets.2025.1644003/full
Ετικέτες:	Προσθήκη ετικέτας Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!