Pharmacometrics modeling and simulation to assist phenobarbital dose optimization in dogs

IntroductionPhenobarbital (PB) remains the first-line treatment for canine epilepsy due to its efficacy, affordability, and favorable pharmacokinetics. However, its narrow therapeutic index and substantial interindividual variability necessitate therapeutic drug monitoring (TDM) and individualized d...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Silvana Alvariza, Manuel Ibarra, Natalia Guevara, Cecilia Maldonado, Marta Vázquez, Gimena Feijoó, Gonzalo Suárez
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-09-01
Colecção:	Frontiers in Veterinary Science
Assuntos:	phenobarbital population pharmacokinetics therapeutic drug monitoring model-informed precision dosing canine epilepsy
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fvets.2025.1644003/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!