Dual T/NK cell engagement via B7-H6-targeted bispecific antibodies and IL-15 eradicates chemo-resistant solid tumors

IntroductionB7-H6, a tumor-specific immune checkpoint molecule within the B7 family, represents a promising therapeutic target due to its selective overexpression in malignancies and negligible expression in normal tissues.MethodHere, we developed bispecific antibodies (BsAbs) targeting B7-H6 to red...

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Hlavní autoři:	Xuqian Ma, Huixia He, Yuankui Zhu, Dianbao Zuo, FangLin Wang, Mingqian Feng, Kangkang Ji, Xin Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-08-01
Edice:	Frontiers in Immunology
Témata:	B7-H6 bispecific antibodies NK cells IL-15Rα sushi solid tumor
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1625813/full
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