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Curcumin Nanoparticle Enhances the Anticancer Effect of Cisplatin by Inhibiting PI3K/AKT and JAK/STAT3 Pathway in Rat Ovarian Carcinoma Induced by DMBA

Cisplatin has been used for decades for the treatment of ovarian cancer. However, despite its potent anticancer effect, cisplatin’s efficacy as a single agent was inadequate in patients with advanced stage. Curcumin has been shown to sensitize cisplatin activity in several cancer models. However, th...

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Main Authors: Ni Made Dwi Sandhiutami, Wawaimuli Arozal, Melva Louisa, Deni Rahmat, Puspita Eka Wuyung
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
ovarian carcinoma
cisplatin
curcumin
nanoparticles
TGF-β
interleukin-6
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.603235/full
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