In vitro and in vivo activity of colistin-nitroxoline combination against polymyxin heteroresistant carbapenem-resistant Klebsiella pneumoniae

Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a critical global health threat, often causing life-threatening infections with limited therapeutic options. Polymyxins are often used as the last-line agent, but its efficacy is limited by heteroresistance-where re...

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Hauptverfasser:	Xin Chen, Jianping Jiang, Xiaogang Xu, Xu Zhao, Yijun Deng, Jiachun Su
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-05-01
Schriftenreihe:	BMC Microbiology
Schlagworte:	Carbapenem-resistant Klebsiella pneumoniae Colistin Nitroxoline Heteroresistance Combination therapy
Online-Zugang:	https://doi.org/10.1186/s12866-026-05150-0
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