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In vitro and in vivo activity of colistin-nitroxoline combination against polymyxin heteroresistant carbapenem-resistant Klebsiella pneumoniae

Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a critical global health threat, often causing life-threatening infections with limited therapeutic options. Polymyxins are often used as the last-line agent, but its efficacy is limited by heteroresistance-where re...

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Principais autores: Xin Chen, Jianping Jiang, Xiaogang Xu, Xu Zhao, Yijun Deng, Jiachun Su
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2026-05-01
סדרה:BMC Microbiology
נושאים:
Carbapenem-resistant Klebsiella pneumoniae
Colistin
Nitroxoline
Heteroresistance
Combination therapy
גישה מקוונת:https://doi.org/10.1186/s12866-026-05150-0
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