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Nicotinamide mononucleotide impacts HIV-1 infection by modulating immune activation in T lymphocytes and humanized miceResearch in context

Summary: Background: HIV-1-associated immune activation drives CD4+ T cell depletion and the development of acquired immunodeficiency syndrome. We aimed to determine the role of nicotinamide mononucleotide (NMN), the direct precursor of nicotinamide adenine dinucleotide (NAD) co-enzyme, in CD4+ T c...

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Principais autores: Yufei Mo, Ming Yue, Lok Yan Yim, Runhong Zhou, Chunhao Yu, Qiaoli Peng, Ying Zhou, Tsz-Yat Luk, Grace Chung-Yan Lui, Huarong Huang, Chun Yu Hubert Lim, Hui Wang, Li Liu, Hongzhe Sun, Jun Wang, Youqiang Song, Zhiwei Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-12-01
coleção:EBioMedicine
Assuntos:
HIV-1
AIDS
Nicotinamide mononucleotide
CD4 T cell
T cell activation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2352396423004437
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