mTOR inhibition improves the immunomodulatory properties of human bone marrow mesenchymal stem cells by inducing COX-2 and PGE2

Abstract Background Bone marrow mesenchymal stem cells (MSCs) are promising candidates for the treatment of various inflammatory disorders due to their profound immunomodulatory properties. However, the immunosuppressive capacity of MSCs needs activation by an inflammatory microenvironment, which ma...

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Detalhes bibliográficos

Principais autores:	Binsheng Wang, Yu Lin, Yongxian Hu, Wei Shan, Senquan Liu, Yulin Xu, Hao Zhang, Shuyang Cai, Xiaohong Yu, Zhen Cai, He Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-12-01
coleção:	Stem Cell Research & Therapy
Assuntos:	Mesenchymal stem cells Immunosuppressive properties Immunogenicity TSC-mTOR pathway Rapamycin
Acesso em linha:	http://link.springer.com/article/10.1186/s13287-017-0744-6
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