miRNA-Dependent Regulation of AKT1 Phosphorylation

The phosphoinositide-3-kinase (PI3K)/AKT pathway regulates cell survival and is over-activated in most human cancers, including ovarian cancer. Following growth factor stimulation, AKT1 is activated by phosphorylation at T308 and S473. Disruption of the AKT1 signaling pathway is sufficient to inhibi...

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Autors principals:	Mallory I. Frederick, Tarana Siddika, Pengcheng Zhang, Nileeka Balasuriya, Matthew A. Turk, Patrick O’Donoghue, Ilka U. Heinemann
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-02-01
Col·lecció:	Cells
Matèries:	miRNA posttranslational modification protein phosphorylation oncogenic kinase signaling
Accés en línia:	https://www.mdpi.com/2073-4409/11/5/821
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