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miRNA-Dependent Regulation of AKT1 Phosphorylation

The phosphoinositide-3-kinase (PI3K)/AKT pathway regulates cell survival and is over-activated in most human cancers, including ovarian cancer. Following growth factor stimulation, AKT1 is activated by phosphorylation at T308 and S473. Disruption of the AKT1 signaling pathway is sufficient to inhibi...

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Autori principali: Mallory I. Frederick, Tarana Siddika, Pengcheng Zhang, Nileeka Balasuriya, Matthew A. Turk, Patrick O’Donoghue, Ilka U. Heinemann
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2022-02-01
Serie:Cells
Soggetti:
miRNA
posttranslational modification
protein phosphorylation
oncogenic kinase
signaling
Accesso online:https://www.mdpi.com/2073-4409/11/5/821
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