In Silico and In Vitro Study of Janus Kinases Inhibitors from Naphthoquinones

Janus kinases (JAKs) are involved in numerous cellular signaling processes related to immune cell functions. JAK2 and JAK3 are associated with the pathogenesis of leukemia and common lymphoid-derived illnesses. JAK2/3 inhibitors could reduce the risk of various diseases by targeting this pathway. He...

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Hlavní autoři:	Kamonpan Sanachai, Panupong Mahalapbutr, Lueacha Tabtimmai, Supaphorn Seetaha, Nantawat Kaekratoke, Supakarn Chamni, Syed Sikander Azam, Kiattawee Choowongkomon, Thanyada Rungrotmongkol
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-01-01
Edice:	Molecules
Témata:	JAK2/3 inhibitors naphthoquinones enzymatic and cell-based assay molecular dynamics simulations
On-line přístup:	https://www.mdpi.com/1420-3049/28/2/597
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