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GDF15 ameliorates sepsis-induced lung injury via AMPK-mediated inhibition of glycolysis in alveolar macrophage

Abstract Growth differentiation factor 15 (GDF15) as a stress response cytokine is involved in the development and progression of several diseases associated with metabolic disorders. However, the regulatory role and the underlying mechanisms of GDF15 in sepsis remain poorly defined. Our study analy...

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Principais autores: Shasha Lu, Ranran Li, Yunxin Deng, Ju Bai, Bangqi Ji, Yufeng Chu, Yan Xu, Hongping Qu, Xiaosun Guo, Pibao Li, Mei Meng
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-05-01
Serier:Respiratory Research
Fag:
Growth differentiation factor 15(GDF15)
Glycolysis
Inflammation
sepsis
Alveolar macrophage
Online adgang:https://doi.org/10.1186/s12931-024-02824-z
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