Phenotypes in Brugada syndrome with different genotypes triggered by fever or inflammation using gene-edited iPSCs

Abstract Background Fever or inflammation state may enhance the Brugada syndrome (BrS) phenotype in some but not all patients. However, the underlying mechanism in human cardiomyocytes has not yet been clarified. Methods Human induced pluripotent stem cell (hiPSC) lines generated from fibroblasts of...

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التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Yingrui Li, Lena Rose, Timo Prädel, Mandy Kleinsorge, Xuehui Fan, Zenghui Meng, Chen Yan, Rui Liu, Xinhao Lei, Binyi Zhao, Guoqiang Yang, Zhenxing Liao, Hendrik Dinkel, Alexandra Viktoria Busley, Rujia Zhong, Feng Zhang, Qiang Xu, Lasse Maywald, Assem Aweimer, Mengying Huang, Alexander Moscu-Gregor, Nazha Hamdani, Luca Schneider, Yeweynwuha Zemedi, Saltanat Zhazykbayeva, Alyssa Hohn, Zhen Yang, Lin Qiao, Andreas Mügge, Lukas Cyganek, Xiaobo Zhou, Ibrahim Akin, Ibrahim El-Battrawy
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	BMC 2025-12-01
سلاسل:	Stem Cell Research & Therapy
الموضوعات:	Brugada syndrome Induced pluripotent stem cells Hyperthermia Inflammation
الوصول للمادة أونلاين:	https://doi.org/10.1186/s13287-025-04793-6
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!