Phenotypes in Brugada syndrome with different genotypes triggered by fever or inflammation using gene-edited iPSCs

Abstract Background Fever or inflammation state may enhance the Brugada syndrome (BrS) phenotype in some but not all patients. However, the underlying mechanism in human cardiomyocytes has not yet been clarified. Methods Human induced pluripotent stem cell (hiPSC) lines generated from fibroblasts of...

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Principais autores:	Yingrui Li, Lena Rose, Timo Prädel, Mandy Kleinsorge, Xuehui Fan, Zenghui Meng, Chen Yan, Rui Liu, Xinhao Lei, Binyi Zhao, Guoqiang Yang, Zhenxing Liao, Hendrik Dinkel, Alexandra Viktoria Busley, Rujia Zhong, Feng Zhang, Qiang Xu, Lasse Maywald, Assem Aweimer, Mengying Huang, Alexander Moscu-Gregor, Nazha Hamdani, Luca Schneider, Yeweynwuha Zemedi, Saltanat Zhazykbayeva, Alyssa Hohn, Zhen Yang, Lin Qiao, Andreas Mügge, Lukas Cyganek, Xiaobo Zhou, Ibrahim Akin, Ibrahim El-Battrawy
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-12-01
Serija:	Stem Cell Research & Therapy
Teme:	Brugada syndrome Induced pluripotent stem cells Hyperthermia Inflammation
Online dostop:	https://doi.org/10.1186/s13287-025-04793-6
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