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MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma

<p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation of mitogen activated protein kinase (MAPK) pathway i...

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Príomhchruthaitheoirí: Lin Shibo, Hoffmann Katrin, Xiao Zhi, Jin Nan, Galli Uwe, Mohr Elvira, Büchler Markus W, Schemmer Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: BMC 2013-01-01
Sraith:Cancer Cell International
Ábhair:
Rochtain ar líne:http://www.cancerci.com/content/13/1/3
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