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Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis

Abstract Background P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to the resistance of CRC to 5-fluorouracil. The aim of this study was to i...

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Autori principali: Nhi Huynh, Kai Wang, Mildred Yim, Chelsea J. Dumesny, Mauro S. Sandrin, Graham S. Baldwin, Mehrdad Nikfarjam, Hong He
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2017-06-01
Serie:BMC Cancer
Soggetti:
PAK1
Intestinal tumour
APC
Lymphocytes
Accesso online:http://link.springer.com/article/10.1186/s12885-017-3432-0
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