Knockout of PAK1 and PAK4 supresses tumour growth associated with vasculogenic mimicry inhibition through EphA2–VE-cadherin–MCAM pathway

Abstract Pancreatic ductal adenocarcinoma (PDA) remains largely refractory to anti-angiogenic strategies, and non-endothelial perfusion mechanisms such as vasculogenic mimicry (VM, endothelial-like channels formed by tumour cells) may sustain tumour progression. Here, we examined whether the combine...

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Auteurs principaux:	Arian Ansardamavandi, Chelsea Dumesny, Sarah Ellis, Ching-Seng Ang, Mehrdad Nikfarjam, Hong He
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2026-03-01
Collection:	Cell Communication and Signaling
Sujets:	Pancreatic ductal adenocarcinoma p21-activated kinases Vasculogenic mimicry EphA2 VE-cadherin Hypoxia
Accès en ligne:	https://doi.org/10.1186/s12964-026-02778-3
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