Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology

Abstract Background Upper motor neurons (UMNs) are a key component of motor neuron circuitry. Their degeneration is a hallmark for diseases, such as hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), and amyotrophic lateral sclerosis (ALS). Currently there are no preclinical assay...

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Auteurs principaux:	Barış Genç, Mukesh Gautam, Öge Gözütok, Ina Dervishi, Santana Sanchez, Gashaw M. Goshu, Nuran Koçak, Edward Xie, Richard B. Silverman, P. Hande Özdinler
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2021-02-01
Collection:	Clinical and Translational Medicine
Sujets:	ALS HSP mSOD1 NU‐9 PLS TDP‐43 pathology
Accès en ligne:	https://doi.org/10.1002/ctm2.336
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