COP1 Deficiency in BRAF^V600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway

Aberrant activation of the mitogen-activated protein kinase (MAPK) cascade promotes oncogenic transcriptomes. Despite efforts to inhibit oncogenic kinases, such as BRAFV600E, tumor responses in patients can be heterogeneous and limited by drug resistance mechanisms. Here, we describe patient tumors...

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Detalhes bibliográficos

Principais autores:	Ada Ndoja, Christopher M. Rose, Eva Lin, Rohit Reja, Jelena Petrovic, Sarah Kummerfeld, Andrew Blair, Helen Rizos, Zora Modrusan, Scott Martin, Donald S. Kirkpatrick, Amy Heidersbach, Tao Sun, Benjamin Haley, Ozge Karayel, Kim Newton, Vishva M. Dixit
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-06-01
Colecção:	Cells
Assuntos:	COP1 DET1 BRAF melanoma vemurafenib
Acesso em linha:	https://www.mdpi.com/2073-4409/14/13/975
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