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COP1 Deficiency in BRAF<sup>V600E</sup> Melanomas Confers Resistance to Inhibitors of the MAPK Pathway

Aberrant activation of the mitogen-activated protein kinase (MAPK) cascade promotes oncogenic transcriptomes. Despite efforts to inhibit oncogenic kinases, such as BRAFV600E, tumor responses in patients can be heterogeneous and limited by drug resistance mechanisms. Here, we describe patient tumors...

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Principais autores: Ada Ndoja, Christopher M. Rose, Eva Lin, Rohit Reja, Jelena Petrovic, Sarah Kummerfeld, Andrew Blair, Helen Rizos, Zora Modrusan, Scott Martin, Donald S. Kirkpatrick, Amy Heidersbach, Tao Sun, Benjamin Haley, Ozge Karayel, Kim Newton, Vishva M. Dixit
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2025-06-01
סדרה:Cells
נושאים:
COP1
DET1
BRAF
melanoma
vemurafenib
גישה מקוונת:https://www.mdpi.com/2073-4409/14/13/975
תגים: הוספת תג
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