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Menin Reduces Parvalbumin Expression and is Required for the Anti‐Depressant Function of Ketamine

Abstract Dysfunction of parvalbumin (PV) neurons is closely involved in depression, however, the detailed mechanism remains unclear. Based on the previous finding that multiple endocrine neoplasia type 1 (Protein: Menin; Gene: Men1) mutation (G503D) is associated with a higher risk of depression, a...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Lige Leng, Kai Zhuang, Hui Lin, Jinjun Ding, Shangchen Yang, Ziqi Yuan, Changquan Huang, Guimiao Chen, Zhenlei Chen, Mengdan Wang, Han Wang, Hao Sun, Huifang Li, He Chang, Zhenyi Chen, Qi Xu, Tifei Yuan, Jie Zhang
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Wiley 2024-02-01
Rangatū:Advanced Science
Ngā marau:
depression
epigenetics
ketamine
menin
parvalbumin
Urunga tuihono:https://doi.org/10.1002/advs.202305659
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