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Qualitative beta-2-adrenoceptor signaling in the regulation of human airway epithelia mucin and cytokine production

Abstract Background Numerous in vivo studies have demonstrated beta-2-adrenoceptor (β2AR) -agonism as permissive in the development of allergic lung inflammation, and have implicated the arrestin-dependent signaling arm of the β2AR in mediating this effect. However, the specific cell type(s) mediati...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Fred Graumuller, Diana Cervantes, Tung O. Chan, Niccolette Schaunaman, Dominic R. Villalba, Burton F. Dickey, Julia K. L. Walker, Hong Wei Chu, Raymond B. Penn
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-05-01
Schriftenreihe:Respiratory Research
Schlagworte:
Asthma
Inflammation
Protein kinase A
Beta-arrestin
G protein
Biased signaling
Online-Zugang:https://doi.org/10.1186/s12931-026-03693-4
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