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Comprehensive single-cell RNA-sequencing study of Tollip deficiency effect in IL-13-stimulated human airway epithelial cells

Abstract Objective Toll-interacting protein (Tollip) suppresses excessive pro-inflammatory signaling, but its function in airway epithelial responses to IL-13, a key mediator in allergic diseases, remains unclear. This study investigates Tollip knockdown (TKD) effects in primary human airway epithel...

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Principais autores: Grace Yihua Lee, Niccolette Schaunaman, Hamid Reza Nouri, Monica Kraft, Hong Wei Chu
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2025-04-01
סדרה:BMC Research Notes
נושאים:
Tollip
IL13 or IL-13
TNF-α signaling
Inflammatory response
Epithelial–mesenchymal transition
Basal cells
גישה מקוונת:https://doi.org/10.1186/s13104-025-07255-7
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