A Novel MVA-Based HIV Vaccine Candidate (MVA-gp145-GPN) Co-Expressing Clade C Membrane-Bound Trimeric gp145 Env and Gag-Induced Virus-Like Particles (VLPs) Triggered Broad and Multifunctional HIV-1-Specific T Cell and Antibody Responses

The development of an effective Human Immunodeficiency Virus (HIV) vaccine that is able to stimulate both the humoral and cellular HIV-1-specific immune responses remains a major priority challenge. In this study, we described the generation and preclinical evaluation of single and double modified v...

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Principais autores:	Beatriz Perdiguero, Cristina Sánchez-Corzo, Carlos Oscar S. Sorzano, Lidia Saiz, Pilar Mediavilla, Mariano Esteban, Carmen Elena Gómez
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2019-02-01
Series:	Viruses
Assuntos:	HIV-1 MVA vaccine Env-gp145 Gag-Pol-Nef VLPs immunogenicity CD4 T cells Tfh GC B cells humoral responses
Acceso en liña:	https://www.mdpi.com/1999-4915/11/2/160
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