IL6 receptor inhibitors: exploring the therapeutic potential across multiple diseases through drug target Mendelian randomization

BackgroundHigh interleukin-6 levels correlate with diseases like cancer, autoimmune disorders, and infections. IL-6 receptor inhibitors (IL-6Ri), used for rheumatoid arthritis and COVID-19, may have wider uses. We apply drug-target Mendelian Randomization (MR) to study IL-6Ri’s effects.MethodTo simu...

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Hlavní autoři:	Chong Fu, Longquan Wang, Wenjiao Cai
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-08-01
Edice:	Frontiers in Immunology
Témata:	IL-6 receptor Mendelian randomization idiopathic pulmonary fibrosis Parkinson’s disease type 2 diabetes
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1452849/full
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