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Single-chain variable fragment affinity tuning can optimize anti-AML CAR-NK cell functionality

Background Natural Killer (NK) cells have intrinsic anticancer activity that can be redirected toward acute myeloid leukemia (AML) with chimeric antigen receptor (CAR) engineering. Here, we study the functional consequences of CAR binding affinity and targeted epitope on CAR-NK cell activation, cyto...

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Gorde:
Egile Nagusiak: Marianna Zahurak, Ravi Varadhan, Ilias Christodoulou, Ruyan Rahnama, Jun Choe, Huilin Yang, Monika Kizerwetter, Christian Guaraca, Natalie Jordan Holl, Stamatia C Vorri, Megan Zinsky, Danielle G Jones, Nikol Garcia Espinoza, Yun-Huai Kuo, Jamie B. Spangler, Challice L. Bonifant
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMJ Publishing Group 2025-02-01
Saila:Journal for ImmunoTherapy of Cancer
Sarrera elektronikoa:https://jitc.bmj.com/content/13/2/e010763.full
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